Tile Settings can only be edited directly by the user when editing the dashboard/tile.
Can you share more details about your use case? What kind of data / setting are you trying to change?
There might be other ways to accomplish what you’re looking for. For example, I’ve used Local Storage whenever I want to store settings unique to each browser or cache data for my Custom Tiles. It can be read by other Custom Tiles, which can be a good or bad thing depending on the type of data you are storing and if you want cross-interaction.
For example, here’s a demo using Local Storage to communicate events in real-time across two Custom Tiles: Custom Tile - cross tile eventing